I have the exact same problem.
Desktop icon positions are no more remembered after logoff (auto arrange is disabled). All icons shift to the left after logon.
It happened the first time after ESS had blocked a "potentially unwanted application" during a download attempt.
My system is Win10 Home 64 Bit - German version !!!
I have opened a trouble ticket with ESET support last Thursday but didn't get any response as yet.
ESET team, please advise! This is very frustrating!!!