Hi @JozefG
I posted this information earlier and assumed you needed other information and could only think of the Server OS version that was missing, sorry.
ESET Management Agent 10.0.1126.0
ESET Server Security 10.0.12014.0
Detection Engine 28365P (20231207)
Modules status Updated
That said, I did another couple of tests and it seems like it is working now. The cached copy of the profile is being removed at logoff. I guess I was convinced the server was rebooted after the update of the Configuration Module, guess not. I'll keep an eye on it for a couple a days and report back in the coming week.