Again, having been victimized by what amounted to false positives in the past (not by ESET, this is my first time using ESET), wherein critical system files were flagged and quarantined, I am very much in favor of not doing auto cleaning.
I am interested in hearing more about situations where "it's not always possible to display an alert window". When would that be?
Also, I am using Sandboxie as my chief line of defense, and in all honesty, because of its strong capabilities, I don't have the same sense of urgency about AVs that I once had.