Same here. My NOD32 Antivirus 4 (Business Edition) was stuck on 10434 and wouldn't update, manually or otherwise. It continued to say "Update of the virus signature database not necessary" and "The installed virus signature database is current." Of course, I knew it was not current. These signatures were over 24 hours old. Suddenly, right after I created an account on forum.eset.com to post this comment, it finally allowed me to manually update to the current signatures (10440). This manual update procedure had failed to work, many times today. Strange.