On a Mac/Big Sur ( using Eset C/S Pro ) An issue with WEB/MAIL not activating I found that ESET Network Protection Proxy , required me to tick the connect on demand box 'every time' the computer was started. ( its found in the apple icon "system preferences/network" )
I was running Surfshark VPN on WireGuard so I changed the Surfshark setting back to Automatic IKEv2 , this solved the problem of the WEB/EMAIL protection failing to start after a reboot. (I no longer need to tick the sys pref/network)
I tried it again with WireGuard on and the issue returned so theres definitely a conflict between the VPN and ESET there may be other conflicts however this fixed my issue.