The ESET Email Protection settings are and remain the ESET "default", where both POP3 and IMAP are enabled, with POP3 using ports 110, 995 and IMAP using 143, 585, 993.
Note: I had installed ESET v6.10.460.1 while still on MacOS Big Sur v11.0.1 and everything worked fine, including the mail connection/retrievals. I was able to update to Big Sur v11.1 yesterday and upon boot into the OS, I noticed all the e-mail accounts were stuck on "connecting..." and eventually timing out and going offline in the default MacOS mail app. When I turn off/disable the E-mail client protection, the mailbox connections and retrievals work again. I've left the option turned off so I can get my e-mails, but it is annoying to see the red hazard icon warning me of "Disabled Protection". I had changed nothing within ESET's default settings and nothing within the MacOS other than installing the v11.1 delta update to my previous v11.01. There is something that changed within the MacOS v11.1 update that perhaps affects ESET's Email client protection. Web access protection and Anti-Phishing protections on the surface seem to be unaffected.