No, I've been using Nod32 for some time now (years, but just re-installed this computer a couple of months ago, the first scan was slow *smile*), and the in-depth scan time is about 30 minutes. That isn't bad, but this is a fast computer (SSD and Core i7 processor), so it should scan quickly.
And thanks for the tips on file system cleanup...I'll look into that, but what amazes me is that Nod32 says that it is scanning 1.1 million files, while only 140,000 files (closer to the actual number of physical files, I'm sure) are found on my computer.
I'm going to play around and see if I can find files to scan that Nod32 reports more than 1 file for. I can assess what's going on when I identify those files (I expect that they are archives of some sort).