Is the equation e=mc^2?

(454)*(299 792 458)^2

(454) * 89,875,517,873,681,764 = 40,803,485,114,651,520,856

If this is what is required, what energy value is being used? Joules, watts?

This is just an exercise to see how much energy it would take to accelerate 1 lb to light speed.