I'm currently running the Insiders Preview. Since there are so many builds being released and Eset would have to update individual versions to support them, I'm not using NOD32. I'm using Defender instead, only for the moment. I'll be jumping to the the final RTM version of Windows 10 as it comes out. I hope Eset has plans to support it right away 'cause I miss my favorite security software.
BTW, Windows 10 is looking very good.