This is still occurring after upgrading to OSX 10.11.1 and I believe it got worse, usually I have freezing issues after serval hours (lets say 4 hours).
But yesterday after the upgrade I had the problem within 30 min and twice in a row.
I'n not sure what happens with a different user, I just ended up uninstalling Eset for now and everything is good again.
I'm running currently a evaluation version which is about to end, so for now I'll wait purchasing a licence till this is fixed.