ESET Smart Security cleaner module 1113 resolved my problem of Windows 10 icons constantly resetting to the default position (along left side of screen).
A number of prior posts here, and on Win10 forums, noted this same problem. I tried all of the "simple solutions" but none worked for me. I did not, however, do the registry changes suggested by some because of ESET Moderators comments. I opted to wait for new ESET cleaner modules. Although 1112 did not fix this problem for me, 1113 did do so. Thank you ESET for fixing this: all things considered it was a minor problem but one that was driving me crazy.