Hello.
I have just experienced the same problem.
I started up my mac this morning and a window popped up saying "cannot connect to /tmp/esets.sock: connection refused".
I have not updated any software or anything like that since yesterday.
Please can you advise me what to do.
I am running OSX 10.8.5
ESet version - i can only assume it is the latest one because it updates itself?
Thank you.