Hi Marcos,
The 'Roaming' part of the user profile is saved to the file-server on logoff. After that the local copy of the roaming profile is deleted. (GPO: Computer Configuration -> System -> User Profiles -> Delete cached copies of roaming profiles)
I did add '%UserProfile%\AppData\Roaming\ESET\ESET Security\*' in the Performance exclusions.
Now I have replaced this with your suggestion: 'C:\Users\*\AppData\Roaming\ESET\ESET Security'.
Also I have added 'C:\ProgramData\ESET\ESET Security' to the exclusions now.
Tonight I will reboot the XenApp-servers and delete the double profiles, I will keep you posted.
Thank you for your support,
Kind regards,
Roel