You wrote that you had Endpoint configured to connect through http proxy.
Please refer to the Troubleshooting section at https://help.eset.com/protect_deploy_va/90/en-US/enable_apache_http_proxy.html:
If you get the EPNS service servers are not accessible Web Console error, follow these steps to disable the connection timeout limits:
1.Create a configuration file reqtimeout.conf: sudo touch /etc/httpd/conf.d/reqtimeout.conf
2.Open the file in a text editor: nano /etc/httpd/conf.d/reqtimeout.conf
3.Type this setting into the file: RequestReadTimeout header=0 body=0
4.Save the changes a close the file:
CTRL+X > type Y > press Enter
5.Open the httpd.conf file: nano /etc/httpd/conf/httpd.conf
6.Add the following line at the end: IncludeOptional conf.d/reqtimeout.conf
7.Save the changes a close the file:
CTRL+X > type Y > press Enter
8.Restart the Apache HTTP Proxy service: systemctl restart httpd
Then re-configure Apache http proxy as follows:
1, Either disable the module reqtimeout_module
2, Or disable limits, ie. by creating a new file reqtimeout.conf in /etc/httpd/conf.d/ and setting "RequestReadTimeout header=0 body=0". Include the file in the configuration, ie. add "IncludeOptional conf.d/reqtimeout.conf" to /etc/httpd/conf/httpd.conf.