I reinstalled Google Chrome 64-bit and the same issue came up. I was also noticing my other 64-bit apps would lag or lockup sometimes.
I didn't want to roll the dice anymore so I uninstalled Smart Security 8 and now all my apps are working perfectly again.
The uninstall process was a bear. Smart Security uninstaller was hanging. The uninstall method that ended up working was downloading the full offline version of Smart Security (ess_nt64_enu.msi), right clicking on the .msi file and choosing Uninstall. This fully worked.
The whole ESET Smart Security experience was a total turn off for me.
My system: Windows 7 64-bit