There are tons of applications besides the operating system itself which write into that folder. You can redirect the system temporary folder by adjusting the system temp / tmp variables. As for user temporary folders, you'd need to redirect user profiles folder.
Personally I don't know anybody with SSD drives who would do that just to minimize writing to a SSD drive. I too use SSD in a notebook and 2 computers with default temp folder settings.
Although many applications write to the temp folders but I didn't find any of them (at least in my PC) writing big files. I'm not sure if I got the correct figure (I got it from Task Manager), NOD32 writes tens of GB of temp files during my weekly full scan and that's quite significant.
I've already moved my temp folder to another drive but I just think it would be nice if NOD32 provides an option so that other applications will not be affected.