Eset is one of the best AV products, but no AV product can protect against nonreplicating malware which has never been seen before. Much of today's malware falls into that category, often being spread by way of spoofing users into installing fake 'updates.'
The flood of updates is in turn mainly created by the security issues with C and SQL. And, to a lesser extent, by Javascript XSS issues.
You might find this applet helpful in preventing spoof attacks. It basically stops executables from being launched in typical browser download folders, and unlike UAE, it can't be absentmindedly O