That article only talks about Windows 7, Windows Server 2008 R2, Windows Server 2008, or Windows Vista not windows 10, the bottom line is no issues without nod32 and there are issues with why should i trust some third party app that i dont know what it does exactly, if i had to go into the windows registry to change some things i would least know what is its changing, unlike that executable.
Sorry for reacting overly paranoid but i think if the software requires these kind of things to be done by normal user its probably bad software to begin with, it should run as advertised and not do anything else, no performance hampering on network trafic, you can patch your software or i just find another anti virus, i don't mind testing a beta of nod32 anti virus to see how that runs while doing large file transfer over my network.