Some progress on my end... or so it would seem. Now, please understand that I am not shilling for the competition, but I downloaded and ran the trial version of Malwarebytes this morning (full log file available if you want it). It identified two registry-related issues, which were quarantined:
Since restarting, I have had zero recurrences of the notification from ESET -- going on a total of four hours of continuously monitored operation. Aware that I am less qualified to comment on whether this is the solution or just a coincidence, I leave it to the pros. I have also run the ESET Log Collector since I used Malwarebytes if anyone would like to view the post-cleaning ESET log for the purposes of comparison.