We've been using ESET for years here at my organisation, long before I started, and I have overseen the upgrade from ESET v4 running NOD32 up to ESET v6.6 running Endpoint Antivirus.
Once I got my head around the fact that it required an Agent first, then the antivirus, it's been a breeze.
However I feel that the reporting is somewhat lacking in terms of filters. For example - when I go to 'Threats', then click on 'Add Filter', I expected to be able to filter by the visible 'Action' column - so I could only select everything that had been Cleaned by Deleting and Mark as Resolved. Unfortunately there is no option to add a filter for that 'Action' column. Some columns that are visible in that report seemed to be inexplicably missing as Filter options.
I was also trying to filter the 'Installed ESET Applications' dashboard report so that it excluded both the ESET Remote Administrator Server and the ESET Rogue Detection Sensor. I discovered that it is only possible to add one entry in that field, and each field can only be added once.
It's likely that there is a reason for such limitations on reporting but it is annoying.