I figured I would update this for anyone who might happen upon it with this problem.
So I took the plunge and then reinstalled ESet, (after having installed libc6:i386 last month) fully expecting to see the same slowdown problems. I'm glad to say that everything seems to be working great for about 24 hours now. Eset UI comes up really quick (faster than Windows), and I ran a couple of scans without problems. If things turn south, I'll let you know, but this seems to be the solution for Ubuntu 16.
ESET SUPPORT: It would be great if you added a note for Ubuntu 16 users in your installation doc advising users to install libc6:i386. And thanks for the help!