Hello, we have same problem since 20.4. Runned on 4.5.3. I had to kill esets daemons every 20 minutes. Functional workaround was downgrade to 4.0.10. Our supplier told me, that the problem is Horus antispam module. That problem is already fixed, but because of another problem with auto update it hasn't been shipped to our system. But, as I have info, that module can be updated manually (sorry, I do not have more complex information how to do it) and than should 4.5.3 work normally.